Synergistic enhancement of bone formation and healing by stem cell–expressed VEGF and bone morphogenetic protein-4
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چکیده
منابع مشابه
Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4.
We investigated the interaction between angiogenic and osteogenic factors in bone formation and bone healing with ex vivo gene therapy using muscle-derived stem cells genetically engineered to express human bone morphogenetic protein-4 (BMP4), VEGF, or VEGF-specific antagonist (soluble Flt1). Our results show that although VEGF alone did not improve bone regeneration, it acted synergistically w...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2002
ISSN: 0021-9738
DOI: 10.1172/jci15153